tissue plasminogen activator (Innovative Research Inc)

Innovative Research Inc is a verified supplier

Innovative Research Inc manufactures this product

About

News

Press Release

Team

Advisors

Partners

Contact

Bioz Stars

Bioz vStars

Buy from Supplier

Structured Review

Innovative Research Inc tissue plasminogen activator
Tissue Plasminogen Activator, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+tpa/Human+Total+tPA+ELISA+Kit%2CHuman+tPA+Total+Antigen+ELISA+Kit/10__1182_slash_blood___2025___5252-6-35-40
Average 93 stars, based on 7 article reviews

tissue plasminogen activator - by Bioz Stars, 2026-09

93/100 stars

Images

Incubation:

Article Title: Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
Article Snippet: .. TABLE 12 Summary statistics of substrate cleavability >20% <20% Cleavage Cleavage <20% with 50 nM >20% >20% with Cleavage <20% Matriptase- Cleavage Cleavage with 500 pM with Cleavage Discovery Substrate 1 or 50 nM with 50 nM 50 nM Plasmin or 500 pM with effort Group uPA uPA Matriptase-1 50 nM tPA Plasmin 50 nM tPA Matriptase- All 100% 78% 75% 76% 76% 96% and uPA- Matriptase- (51 of 51) (40 of 51) (38 of 51) (39 of 51) (39 of 51) (49 of 51) selected and uPA- Substrates selected Substrates tested Substrates 100% 64% 89% 89% 89% 93% from Pools (28 of 28) (18 of 28) (25 of 28) (25 of 28) (25 of 28) (26 of 28) Consensus 100% 96% 57% 61% 61% 100% Substrates (23 of 23) (22 of 23) (13 of 23) (14 of 23) (14 of 23) (23 of 23) Matriptase- All 86% 41% 67% 70% 82% 85% selected Matriptase- (83 of 97) (40 of 97) (65 of 97) (68 of 97) (80 of 97) (82 of 97) Substrates selected Substrates Substrates 81% 35% 62% 81% 94% 87% from Pools (42 of 52) (18 of 52) (32 of 52) (42 of 52) (49 of 52) (45 of 52) Consensus 91% 49% 73% 58 69% 82% Substrates (41 of 45) (22 of 45) (33 of 45) (26 of 45) (31 of 45) (37 of 45) Combined Total 91% 54% 70% 72% 80% 89% substrates (134 of 148) (80 of 148) (103 of 148) (107 of 148) (119 of 148) (131 of 148) selected for cleavage by Matriptase and/or uPA Table 12 depicts the percentage of Matriptase- and uPA-selected Substrates or Matriptase-selected Substrates tested in the CYTX-DP display platform (a) that exhibited greater than 20% cleavage when incubated with 50 nM human uPA (catalog no. 1310-SE, Research & Diagnostics Systems, Inc.) used without modifications for 1 hour at 37° C. in 50 mM Tris-HCl, 150 mM NaCl, 0.05% Tween20, pH 7.4 (TBST) (>20% cleavage with 50 nM uPA); (b) that exhibited greater than 20% cleavage when incubated with 50 nM human matriptase-1 (catalog no. 3946-SE, Research & Diagnostics Systems, Inc.) used without modifications for 1 hour at 37° C. in 50 mM Tris-HCl, 150 mM NaCl, 0.05% Tween20, pH 7.4 (TBST) (>20% cleavage with 50 nM matriptase-1); (c) that exhibited less than 20% cleavage when incubated with 500 pM human plasmin (catalog no. HCPM-0140, Haematologic Technologies, Inc.) used without modifications for 1 hour at 37° C. in 50 mM Tris-HCl pH 7.5 supplemented with 100 mM NaCl, 0.01% Tween20 and 1 mM EDTA (<20% cleavage with 500 pM plasmin); and (d) that exhibited less than 20% cleavage when incubated with 50 nM human tPA (catalog no. HTPA-TC, Molecular Innovations) used without modifications for 1 hour at 37° C. in 50 mM Tris-HCl, 150 mM NaCl, 0.05% Tween20, pH 7.4 (TBST) (<20% cleavage with 50 nM tPA). ..

other:

Article Title: Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
Article Snippet: Human tPA (Molecular Innovations) was used without modifications.

Produced:

Article Title: A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue.
Article Snippet: .. Final concentrations of serine proteases were the following: human uPA (UPALMW, from human urine, 33 kDa; Molecular Innovations, Novi, MI, USA) 1.5 nM, mouse uPA (MUPA-LMW, recombinantly produced in insect cells, 31 kDa; Molecular Innovations, Novi, MI, USA) 12 nM, human tPA (HTPATC, recombinant, 70 kDa; Molecular Innovations, Novi, MI, USA) 7.5 nM, mouse tPA (MTPA, recombinantly produced in insect cells, 70 kDa; Molecular Innovations, Novi, MI, USA) 6 nM, human trypsin (HTRYP, from human pancreas, 25 kDa; Molecular Innovations, Novi, MI, USA) 0.05 nM, human plasmin (HPLM, from human plasma, 85 kDa; Molecular Innovations, Novi, MI, USA) 1.5 nM, human plasma kallikrein (IHPKA, from human plasma, 86 kDa; Innovative Research, Novi, MI, USA) 0.5 nM, human thrombin (IHT, from human plasma, 37 kDa, Innovative Research, Novi, MI, USA) 10 nM, human factor XIIa (IHFXIIa, from human plasma, 80 kDa; Innovative Research, Novi, MI, USA) 6 nM, human factor Xa (HCXA-0060, Haematologic Technologies, Essex, VT, USA) 1 nM, human factor XIa (HCXIA-0160, Haematologic Technologies, Essex, VT, USA) 10 nM, human factor VIIa (HCVIIA-0031, Haematologic Technologies, Essex, VT, USA) 100 nM and human activated protein C (HCAPC-0080, Haematologic Technologies, Essex, VT, USA) 10 nM. ..

Recombinant:

Clinical Proteomics:

Article Title: Combination of Coevolutionary Information and Supervised Learning Enables Generation of Cyclic Peptide Inhibitors with Enhanced Potency from a Small Data Set
Article Snippet: .. Final concentrations of serine proteases were the following: human uPA (UPA-LMW, Molecular Innovations, Novi, MI, USA) 1.5 nM, mouse uPA (MUPA-LMW, Molecular Innovations, Novi, MI, USA) 12 nM, human tPA (HTPATC; Molecular Innovations, Novi, MI, USA) 7.5 nM, mouse tPA (MTPA, Molecular Innovations, Novi, MI, USA) 6 nM, human trypsin (HTRYP, Molecular Innovations, Novi, MI, USA) 0.05 nM, human plasmin (HPLM, Molecular Innovations, Novi, MI, USA) 1.5 nM, human plasma kallikrein (IHPKA, Innovative Research, Novi, MI, USA) 0.5 nM, human thrombin (IHT, Innovative Research, Novi, MI, USA) 10 nM, and human factor XIIa (IHFXIIa, Innovative Research, Novi, MI, USA) 6 nM. ..

Review